Guillermo García Calvo has a long career as a conductor on international stages such as the Deutsche Oper Berlin, the Wiener Staatsoper or the Paris Opera, among others, and Spanish stages such as the Opera of Oviedo, the Gran Teatre del Liceu of Barcelona or the Teatro Real and the Teatro de la Zarzuela in Madrid.

He was Generalmusikdirektor of the Chemnitz Opera (Germany) and Principal Conductor of the Robert-Schumann-Philharmonie from 2017 to 2024, giving the works of Richard Wagner an important role in the repertoire of that theater and creating a new production of the cycle Der Ring des Nibelungen, one of whose operas, Götterdämmerung (Twilight of the Gods) received in 2019 the Faust prize for the best opera production in Germany.

From 2020 to 2024 he was also Musical Director of the Teatro de la Zarzuela in Madrid.

Guillermo García Calvo conducts operas and concerts in the most prominent theaters, such as Siegfried (Opera of Oviedo), which won him the Opera XXI award for best musical direction in the 2017/18 season, Katiuska (Teatro de la Zarzuela), La Gioconda (Gran Teatre del Liceu), with which he won the Amics del Liceu Critics Award for best musical direction, L'elisir d'amore at the New National Theater in Tokyo or Don Giovanni at the Opéra de Paris.